Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col2a1  collagen, type II, alpha 1   (Synonyms: Col2, Col2a, Col2a-1, Del1, Lpk, M100413, M100856, Rgsc413, Rgsc856)
Results	Reference
1	J:67299 Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y, Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
1	J:189073 Benazet JD, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R, Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development. 2012 Nov;139(22):4250-60
1	J:251599 Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W, MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. Biochim Biophys Acta. 2016 Dec;1863(12):2881-2891
1*	J:309441 Chien C, Pryce B, Tufa SF, Keene DR, Huang AH, Optimizing a 3D model system for molecular manipulation of tenogenesis. Connect Tissue Res. 2018 Jul;59(4):295-308
1	J:293351 Eyal S, Kult S, Rubin S, Krief S, Felsenthal N, Pineault KM, Leshkowitz D, Salame TM, Addadi Y, Wellik DM, Zelzer E, Bone morphology is regulated modularly by global and regional genetic programs. Development. 2019 Jul 26;146(14):dev167882
1	J:272612 Eyal S, Rubin S, Krief S, Levin L, Zelzer E, Common cellular origin and diverging developmental programs for different sesamoid bones. Development. 2019 Feb 28;146(4):dev167452
1	J:215404 Hering TM, Wirthlin L, Ravindran S, McAlinden A, Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5' splice site within Col2a1 exon 2. Matrix Biol. 2014 Jun;36:51-63
1	J:260150 Hisanaga S, Miyake M, Taniuchi S, Oyadomari M, Morimoto M, Sato R, Hirose J, Mizuta H, Oyadomari S, PERK-mediated translational control is required for collagen secretion in chondrocytes. Sci Rep. 2018 Jan 15;8(1):773
1	J:109399 Ichikawa Y, Sumi M, Ohwatari N, Komori T, Sumi T, Shibata H, Furuichi T, Yamaguchi A, Nakamura T, Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings. Bone. 2004 Apr;34(4):619-28
1*	J:194983 Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K, Nifuji A, Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90
1	J:81856 Ihanamaki T, Saamanen AM, Suominen J, Pelliniemi LJ, Harley V, Vuorio E, Salminen H, Expression of Sox9 and type IIA procollagen during ocular development and aging in transgenic Del1 mice with a mutation in the type II collagen gene. Eur J Ophthalmol. 2002 Nov-Dec;12(6):450-8
1	J:155442 Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M, Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res. 2008 Nov;23(11):1751-64
1	J:184499 Lewis R, Ravindran S, Wirthlin L, Traeger G, Fernandes RJ, McAlinden A, Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model. Matrix Biol. 2012 Apr;31(3):214-26
1	J:208830 Lin SS, Tzeng BH, Lee KR, Smith RJ, Campbell KP, Chen CC, Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1990-8
1	J:197791 Masago Y, Hosoya A, Kawasaki K, Kawano S, Nasu A, Toguchida J, Fujita K, Nakamura H, Kondoh G, Nagata K, The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation. J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28
1	J:91587 Mates L, Nicolae C, Morgelin M, Deak F, Kiss I, Aszodi A, Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biol. 2004 Jun;23(3):195-204
1	J:316165 Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R, Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol. 2021 Nov 3;4(1):1258
1	J:255459 Nara M, Kitamura K, Yamamoto M, Nagakura R, Mitomo K, Matsunaga S, Abe S, Developmental mechanism of muscle-tendon-bone complex in the fetal soft palate. Arch Oral Biol. 2017 Oct;82:71-78
1*	J:265842 Palagano E, Zuccarini G, Prontera P, Borgatti R, Stangoni G, Elisei S, Mantero S, Menale C, Forlino A, Uva P, Oppo M, Vezzoni P, Villa A, Merlo GR, Sobacchi C, Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1. Bone. 2018 Sep;114:125-136
1*	J:221086 Patra D, DeLassus E, Liang G, Sandell LJ, Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. 2014;9(8):e105674
1	J:258274 Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ, Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018 Feb 22;7(2):bio032094
1	J:95068 Savontaus M, Rintala-Jamsa M, Morko J, Ronning O, Metsaranta M, Vuorio E, Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene. Orthod Craniofac Res. 2004 Nov;7(4):216-26
1	J:45403 Shibata S, Fukada K, Suzuki S, Yamashita Y, Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible. J Anat. 1997 Nov;191(Pt 4):561-70
1	J:141868 Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H, Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem. 2008 Sep 5;283(36):24682-9
1*	J:146224 Staverosky JA, Pryce BA, Watson SS, Schweitzer R, Tubulin polymerization-promoting protein family member 3, Tppp3, is a specific marker of the differentiating tendon sheath and synovial joints. Dev Dyn. 2009 Mar;238(3):685-92
1*	J:209518 Ushijima T, Okazaki K, Tsushima H, Iwamoto Y, CCAAT/enhancer-binding protein beta regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. J Biol Chem. 2014 Jan 31;289(5):2852-63
1	J:101174 Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff J, Huso DL, Jabs EW, Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005 Aug;132(15):3537-48
1	J:281388 Xu J, Huang Z, Wang W, Tan X, Li H, Zhang Y, Tian W, Hu T, Chen YP, FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. J Dent Res. 2018 May;97(5):589-596
1	J:172282 Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ, Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One. 2011;6(4):e18795